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Phenotypes Associated with This Genotype
Genotype
MGI:4850096
Allelic
Composition		 Ptentm2.1Ppp/Ptentm2.1Ppp
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (87 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased germinal center B cell number ( J:164283 )
• following immunization
increased T follicular helper cell number ( J:164283 )
• 3-fold following immunization
increased IgG1 level ( J:164283 )
• following immunization, mice exhibit an increased in high-affinity antibody titers compared to in similarly treated wild-type mice

hematopoietic system
increased germinal center B cell number ( J:164283 )
• following immunization
increased T follicular helper cell number ( J:164283 )
• 3-fold following immunization
increased IgG1 level ( J:164283 )
• following immunization, mice exhibit an increased in high-affinity antibody titers compared to in similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory