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Phenotypes Associated with This Genotype
Genotype
MGI:4850007
Allelic
Composition
Tg(Igh-TCL1A)1Ypek/0
Genetic
Background
FVB/N-Tg(Igh-TCL1A)1Ypek
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in all mice at 16 to 20 months of age

immune system
• in all mice at 16 to 20 months of age
• splenic CD19+CD5+CD23+ and total CD19+CD5+ cells exhibit proliferation unlike wild-type cells
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months
• MCP-1 serum levels are increased 2-fold compared to in wild-type mice
• SRBC-injected mice exhibit an 8-fold reduction in serum anti-SRBC antibodies unlike similarly treated wild-type mice

neoplasm

homeostasis/metabolism
• MCP-1 serum levels are increased 2-fold compared to in wild-type mice

hematopoietic system
• in all mice at 16 to 20 months of age
• splenic CD19+CD5+CD23+ and total CD19+CD5+ cells exhibit proliferation unlike wild-type cells
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months
• 4- to 8-fold at 18 months


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory