Phenotypes Associated with This Genotype

Genotype
MGI:4849464

• Allelic Composition: Gt(ROSA)26Sor^{tm1(PDGFB)Cbet}/Gt(ROSA)26Sor⁺; Pdgfb^tm1Cbet/Pdgfb^tm1Cbet; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired blood-brain barrier function ( J:166532 )

• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice

• however, imatinib-treatment reverses increased BBB permeability without improving blood vessel morphology

abnormal astrocyte morphology ( J:166532 )

• astrocyte end-feet are mis-localized compared to in wild-type mice

cardiovascular system

abnormal capillary morphology ( J:166532 )

• capillary diameter is increased compared to in wild-type mice

decreased capillary density ( J:166532 )

• capillary density is reduced compared to in wild-type mice

abnormal pericyte morphology ( J:166532 )

• pericyte coverage is less than in wild-type mice but not as severely as in Pdgfb^tm3.1Cbet homozygotes

impaired blood-brain barrier function ( J:166532 )

• mice exhibit increased blood-brain barrier (BBB) permeability compared with wild-type mice

• however, imatinib-treatment reverses increased BBB permeability without improving blood vessel morphology

cellular

abnormal astrocyte morphology ( J:166532 )

• astrocyte end-feet are mis-localized compared to in wild-type mice