Phenotypes Associated with This Genotype

Genotype
MGI:4849446

• Allelic Composition: Col1a1^{tm1(tetO-Lin28a)Gqda}/Col1a1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:166568 )

• following induction with doxycycline associated with marked gut pathology

reproductive system

reproductive system phenotype ( J:166568 )

♀N • despite delayed sexual maturation in female mice, fertility over the first 3 months of life is normal

delayed female fertility ( J:166568 )

♀ • time to first litter is delayed compared with wild-type mice

♀ • however, timing of first estrus is normal

delayed sexual maturation ( J:166568 )

♀ • puberty is delayed in female mice compared with wild-type mice

♀ • at P26, uterine plus ovarian mass is less than in wild-type mice indicating delayed sexual development

♀ • however, timing of first estrus is normal

delayed vaginal opening ( J:166568 )

♀

increased litter size ( J:166568 )

♀ • in the first litter

growth/size/body

broad face ( J:166568 )

• mice exhibit wider faces compared with wild-type mice

big ears ( J:166568 )

increased lean body mass ( J:177113 )

• increase in the percentage of lean mass

decreased susceptibility to age related obesity ( J:177113 )

• gain less fat mass with age compared to wild-type mice on a normal diet

decreased susceptibility to diet-induced obesity ( J:177113 )

• gain less fat mass when fed a high fat diet compared to wild-type mice

• no difference in the consumption of high fat food is detected

increased body size ( J:166568 )

• regardless of doxycycline induction

increased body weight ( J:166568 )

• after weaning

increased body length ( J:166568 )

• after weaning

increased growth rate ( J:166568 )

liver hyperplasia ( J:166568 )

• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:177113 )

• gain less fat mass when fed a high fat diet compared to wild-type mice

• no difference in the consumption of high fat food is detected

decreased circulating glucose level ( J:166568 )

• in fed and fasted states

decreased circulating insulin level ( J:166568 )

• after glucose stimulation

improved glucose tolerance ( J:166568 , J:177113 )

• without increased insulin secretion (J:166568)

• under high fat diet conditions (J:177113)

increased insulin sensitivity ( J:166568 , J:177113 )

• under high fat diet conditions (J:177113)

skeleton

abnormal skeleton morphology ( J:166568 )

• mice exhibit large bones compared with wild-type mice

• mice exhibit bone hyperplasia compared with wild-type mice

increased bone mineral content ( J:166568 )

• bone mineral content is increased compared to in wild-type mice

increased bone mineral density ( J:166568 )

• bone mineral density is increased compared to in wild-type mice

craniofacial

broad face ( J:166568 )

• mice exhibit wider faces compared with wild-type mice

big ears ( J:166568 )

liver/biliary system

increased hepatocyte proliferation ( J:166568 )

• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size

liver hyperplasia ( J:166568 )

• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size

decreased susceptibility to diet-induced hepatic steatosis ( J:177113 )

• under high fat diet conditions

cellular

increased cell proliferation ( J:166568 )

• doxycycline-treated mice exhibit an increase in cell proliferation in the intestinal crypts, blood, and skin compared with wild-type mice

• mice exhibit cell hyperplasia without an increase in cell size

increased hepatocyte proliferation ( J:166568 )

• mice exhibit an increase in cell number compared with wild-type mice without a change in cell size

digestive/alimentary system

abnormal digestive system morphology ( J:166568 )

• following induction with doxycycline, mice exhibit marked gut pathology unlike wild-type mice

hearing/vestibular/ear

big ears ( J:166568 )

endocrine/exocrine glands

small pancreatic islets ( J:166568 )

integument

coarse hair ( J:166568 )

skin hyperplasia ( J:166568 )

thick skin ( J:166568 )

adipose tissue

decreased total body fat amount ( J:177113 )

• decrease in the percentage of body fat