Phenotypes for Tg(GATA5-cre)1Krc Wt1 MGI:4849369 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Wt1^tm1.1Ndha/Wt1^tm1Nhsn Tg(GATA5-cre)1Krc/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GATA5-cre)1Krc mutation (0 available)
Wt1^tm1.1Ndha mutation (0 available); any Wt1 mutation (34 available)
Wt1^tm1Nhsn mutation (1 available); any Wt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:166573 )

• mice die between E16.5 and E18.5 as a result of cardiovascular failure

cardiovascular system

abnormal heart right ventricle morphology ( J:166573 )

• some mice exhibit thinner free walls compared to in wild-type mice

abnormal cardiovascular system physiology ( J:166573 )

• mice die between E16.5 and E18.5 as a result of cardiovascular failure

hemopericardium ( J:166573 )

• mice exhibit pericardial hemorrhaging unlike wild-type mice

poor circulation ( J:166573 )

• at E16.5, mice exhibit an accumulation of blood in the systemic veins unlike in wild-type mice

homeostasis/metabolism

hemopericardium ( J:166573 )

• mice exhibit pericardial hemorrhaging unlike wild-type mice

edema ( J:166573 )

• at E16.5

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