Phenotypes Associated with This Genotype

Genotype
MGI:4848147

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Rictor^tm1.1Mgn/Rictor^tm1.1Mgn
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland duct morphology ( J:144810 )

♂ • prostatic ductules of mutants infected with an adenovirus expressing Cre recombinase exhibit a mixed phenotype containing mostly normal, organized epithelial cells and patches of large, disorganized hyperplastic cells; inefficient deletion of Rictor is seen in the patches of disorganized hyperplastic cells

abnormal prostate gland epithelium morphology ( J:144810 )

♂ • prostate tissue histology of mutants infected with an adenovirus expressing Cre recombinase appears normal except that epithelial cells are slightly smaller

reproductive system

abnormal prostate gland duct morphology ( J:144810 )

♂ • prostatic ductules of mutants infected with an adenovirus expressing Cre recombinase exhibit a mixed phenotype containing mostly normal, organized epithelial cells and patches of large, disorganized hyperplastic cells; inefficient deletion of Rictor is seen in the patches of disorganized hyperplastic cells

abnormal prostate gland epithelium morphology ( J:144810 )

♂ • prostate tissue histology of mutants infected with an adenovirus expressing Cre recombinase appears normal except that epithelial cells are slightly smaller

neoplasm

decreased tumor incidence ( J:144810 )

• mutants infected with an adenovirus expressing Cre recombinase do not develop prostate adenocarcinoma