Analysis Tools
mortality/aging
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• in mice fed a high iron diet and treated with pIpC
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growth/size/body
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• in mice fed a high iron diet and treated with pIpC
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homeostasis/metabolism
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• in mice fed a high iron diet and treated with pIpC
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• in mice fed a high iron diet and treated with pIpC
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• mice fed a high iron diet and treated with pIpC exhibit liver damage (including increased liver weight, swollen liver, enlarged nuclei, macrosteatosis, hemorrhage, infiltration of polymorphonuclear cells, hepatocyte apoptosis, and decreased liver function) and increased lethality compared with Fth1tm1.1Lck homozygotes fed a high iron diet
• pIpC-treated mice injected with iron-dextran exhibit acute liver damage unlike iron-dextran-treated Fth1tm1.1Lck homozygotes
• however, no liver damage is observed in pIpC treated mice fed standard chow
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• in reticuloendothelial cells of pIpC-treated mice
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• mild in pIpC-treated mice
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liver/biliary system
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• in mice fed a high iron diet and treated with pIpC
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• in mice fed a high iron diet and treated with pIpC
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• mice fed a high iron diet and treated with pIpC exhibit swollen livers with infiltration of polymorphonuclear cells unlike in Fth1tm1.1Lck homozygotes fed a high iron diet
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• macrosteatosis in mice fed a high iron diet and treated with pIpC
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immune system
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• in reticuloendothelial cells of pIpC-treated mice
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• mice fed a high iron diet and treated with pIpC exhibit swollen livers with infiltration of polymorphonuclear cells unlike in Fth1tm1.1Lck homozygotes fed a high iron diet
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cardiovascular system
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• in mice fed a high iron diet and treated with pIpC
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hematopoietic system
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• in reticuloendothelial cells of pIpC-treated mice
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