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Phenotypes Associated with This Genotype
Genotype
MGI:4847637
Allelic
Composition
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Stat5a)#Mam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Stat5a)#Mam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups
• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment
• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment
• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5btm2Mam control mice

reproductive system
N
• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups
• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment
• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment
• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5btm2Mam control mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory