Phenotypes for App Psen1 MGI:4847594 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/Psen1^tm1Mpm
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm3.1Zhe mutation (0 available); any App mutation (89 available)
Psen1^tm1Mpm mutation (4 available); any Psen1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Amyloid beta deposits in App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/Psen1^tm1Mpm mice

nervous system

amyloid beta deposits ( J:166379 )

• mice exhibit increased amyloid load compared with App^tm1Ck Psen1^tm1Mpm double homozygotes

homeostasis/metabolism

amyloid beta deposits ( J:166379 )

• mice exhibit increased amyloid load compared with App^tm1Ck Psen1^tm1Mpm double homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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