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Phenotypes Associated with This Genotype
Genotype
MGI:4847555
Allelic
Composition		 Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)1Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland growth during lactation ( J:153755 )
• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy
• produce only a ductal tree with virgin-like characteristics
abnormal mammary gland alveolus morphology ( J:153755 )
• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy
• produce only a ductal tree with virgin-like characteristics
• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy
lactation failure ( J:153755 )
• fail to lactate even after five to six pregnancies

integument
abnormal mammary gland growth during lactation ( J:153755 )
• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy
• produce only a ductal tree with virgin-like characteristics
abnormal mammary gland alveolus morphology ( J:153755 )
• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy
• produce only a ductal tree with virgin-like characteristics
• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy
lactation failure ( J:153755 )
• fail to lactate even after five to six pregnancies

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory