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Phenotypes Associated with This Genotype
Genotype
MGI:4844099
Allelic
Composition		 Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1062 available)
Syktm1.1(cre)Fkfr mutation (0 available); any Syk mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased leukocyte cell number ( J:159112 )
• fetal livers exhibit reduced leukocyte cellularity and colony forming cell frequency compared with wild-type livers
increased leukocyte cell number ( J:159112 )
• at E12.5 and E15.5, abnormal blood vessel morphology is associated with massive leukocyte accumulation
• YFP+ monocyte- or macrophage-like cells accumulate in the skin compared to in Sykbtm1.1(cre)Fkfr/Sykb+ Gt(ROSA)26Sortm1(EYFP)Cos homozygotes

liver/biliary system
abnormal liver development ( J:159112 )
• at E13.5, liver development is reduced compared to in wild-type mice
• fetal livers exhibit reduced leukocyte cellularity and colony forming cell frequency compared with wild-type livers
liver hypoplasia ( J:159112 )
• at E13.5

cardiovascular system
abnormal blood vessel morphology ( J:159112 )
• at E12.5 and E15.5, abnormal blood vessel morphology is associated with massive leukocyte accumulation

hematopoietic system
decreased leukocyte cell number ( J:159112 )
• fetal livers exhibit reduced leukocyte cellularity and colony forming cell frequency compared with wild-type livers
increased leukocyte cell number ( J:159112 )
• at E12.5 and E15.5, abnormal blood vessel morphology is associated with massive leukocyte accumulation
• YFP+ monocyte- or macrophage-like cells accumulate in the skin compared to in Sykbtm1.1(cre)Fkfr/Sykb+ Gt(ROSA)26Sortm1(EYFP)Cos homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory