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Phenotypes Associated with This Genotype
Genotype
MGI:4843964
Allelic
Composition		 Lcp2tm1Gak/Lcp2tm2Gak
Tg(Pf4-icre)Q3Rsko/0
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (942 available)
Lcp2tm1Gak mutation (1 available); any Lcp2 mutation (41 available)
Lcp2tm2Gak mutation (0 available); any Lcp2 mutation (41 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal Peyer's patch morphology ( J:162815 )
• some mice exhibit blood-filled Peyer patches unlike in wild-type mice
abnormal lymphatic vessel morphology ( J:162815 )
• mice exhibit blood-filled mesenteric and intestinal lymphatic vessels unlike wild-type mice

homeostasis/metabolism
abnormal platelet activation ( J:162815 )
• platelets from neonates without vascular phenotypes exhibit intermediate levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

hematopoietic system
abnormal platelet activation ( J:162815 )
• platelets from neonates without vascular phenotypes exhibit intermediate levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory