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Phenotypes Associated with This Genotype
Genotype
MGI:4843962
Allelic
Composition		 Clec1btm1Mlkn/Clec1btm1Mlkn
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec1btm1Mlkn mutation (0 available); any Clec1b mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal platelet activation ( J:162815 )
• platelets are not activated by PDPN-Fc unlike wild-type cells
• however, platelets are normally activated by convulxin

immune system
abnormal lymphatic vessel morphology ( J:162815 )
• at mid-gestation and in neonates, mice exhibit blood-filled mesenteric lymphatics unlike in wild-type mice

digestive/alimentary system

hematopoietic system
abnormal platelet activation ( J:162815 )
• platelets are not activated by PDPN-Fc unlike wild-type cells
• however, platelets are normally activated by convulxin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory