Mouse Genome Informatics
involves: C3H * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increases with age
• the upper arm dentate gyrus exhibits a smaller number of total neurons compared to in wild-type mice
• at 12 months, mice exhibit dystrophic neurites unlike wild-type mice
• at 12 months, mice exhibit an increase in synapse density compared to in wild-type mice
• the synapse to neuron ration increases between 6 and 12 months, declines slightly at 18 months, and falls markedly at 24 months compared to in wild-type mice
• however, synapse density at 18 and 24 months is normal

• at 12 and 18 months, mice exhibit progressive impairment in a Y-maze (a measure of spontaneous alternation behavior) compared with wild-type mice
• however, performance at 2 and 6 months is normal
• at 6, 12, 18, and 24 months but not at 2 months

immune system

hematopoietic system

• increases with age

Mouse Models of Human Disease
Alzheimer Disease; AD 104300 J:128647