Analysis Tools
nervous system
microgliosis
(
J:128647
)
|
• increases with age
|
|
• the upper arm dentate gyrus exhibits a smaller number of total neurons compared to in wild-type mice
|
|
• at 12 months, mice exhibit dystrophic neurites unlike wild-type mice
|
|
• at 12 months, mice exhibit an increase in synapse density compared to in wild-type mice
• the synapse to neuron ration increases between 6 and 12 months, declines slightly at 18 months, and falls markedly at 24 months compared to in wild-type mice
• however, synapse density at 18 and 24 months is normal
|
behavior/neurological
|
• at 12 and 18 months, mice exhibit progressive impairment in a Y-maze (a measure of spontaneous alternation behavior) compared with wild-type mice
• however, performance at 2 and 6 months is normal
|
|
• at 6, 12, 18, and 24 months but not at 2 months
|
immune system
microgliosis
(
J:128647
)
hematopoietic system
microgliosis
(
J:128647
)
homeostasis/metabolism
|
• increases with age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:128647 | ||
