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Phenotypes Associated with This Genotype
Genotype
MGI:4843219
Allelic
Composition
Tg(Thy1-APPSw)10Jiri/0
Genetic
Background
involves: C3H * C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increases with age
• the upper arm dentate gyrus exhibits a smaller number of total neurons compared to in wild-type mice
• at 12 months, mice exhibit dystrophic neurites unlike wild-type mice
• at 12 months, mice exhibit an increase in synapse density compared to in wild-type mice
• the synapse to neuron ration increases between 6 and 12 months, declines slightly at 18 months, and falls markedly at 24 months compared to in wild-type mice
• however, synapse density at 18 and 24 months is normal

behavior/neurological
• at 12 and 18 months, mice exhibit progressive impairment in a Y-maze (a measure of spontaneous alternation behavior) compared with wild-type mice
• however, performance at 2 and 6 months is normal
• at 6, 12, 18, and 24 months but not at 2 months

immune system

hematopoietic system

homeostasis/metabolism
• increases with age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:128647


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory