Phenotypes for Prkaa1 Prkaa2 Tg(Mx1-cre)1Cgn MGI:4840217 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Prkaa1^tm1.1Sjm/Prkaa1^tm1.1Sjm Prkaa2^tm1.1Sjm/Prkaa2^tm1.1Sjm Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1^tm1.1Sjm mutation (1 available); any Prkaa1 mutation (46 available)
Prkaa2^tm1.1Sjm mutation (1 available); any Prkaa2 mutation (33 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:165090 )

N	• hematopoietic stem cells numbers and long-term multi-lineage reconstitution function are normal in pIpC-treated mice

decreased hematopoietic stem cell number ( J:165090 )

• 2-fold in pIpC treated mice

cellular

cellular phenotype ( J:165090 )

N	• hematopoietic stem cells from pIpC treated mice exhibit normal reactive oxygen species or aneuploidy in culture

increased mitochondrial fission ( J:165090 )

• in the hematopoietic stem cells of pIpC-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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