Phenotypes Associated with This Genotype

Genotype
MGI:4839774

• Allelic Composition: Tg(Prnp-PSEN2*N141I)30Jgr/0; Tg(Thy1-APPSwe)71Jgr/0
• Genetic Background: B6.Cg-Tg(Prnp-PSEN2*N141I)30Jgr Tg(Thy1-APPSwe)71Jgr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:165986 )

N • mice exhibit normal LTP

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

cellular

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal