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Phenotypes Associated with This Genotype
Genotype
MGI:4839510
Allelic
Composition
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm8(Erbb2)Mul mutation (0 available); any Erbb2 mutation (59 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer

endocrine/exocrine glands
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer

integument
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:133305


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory