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Phenotypes Associated with This Genotype
Genotype
MGI:4839332
Allelic
Composition
Tg(CAG-RPS19*R62W)#Dmb/0
Tg(Prnp-GFP/cre)1Blw/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-RPS19*R62W)#Dmb mutation (0 available)
Tg(Prnp-GFP/cre)1Blw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice rarely survive beyond weaning
• fewer than expected mice are present at E13.5

hematopoietic system
• at E13.5, the number of R4 and R5 cells is increased compared to in wild-type mice
• at E13.5, the number of R2 cells is decreased 4-fold in the bone marrow and 40-fold in the spleen compared to in wild-type mice
• R3 cells contain 2 nuclei unlike in wild-type mice
• more R4 and R5 cells are uncondensed, nucleated, and poorly hemoglobinized compared to in wild-type mice
• the number of R3 cells in G1 is reduced while the number of cells in the G2/M phase is increased compared to in wild-type mice
• at 4 to 6 weeks, the number of Ter119+ erythroid cells is increased 1.3-fold in the bone marrow and 3.7-fold in the spleen compared to in wild-type mice
• erythroid maturation is inhibited compared to in wild-type mice
• severe at E13.5; mild at 4 to 6 weeks
• the number of BFU-E and CFU-E are decreased in fetal liver and bone marrow compared to in wild-type mice
• at 4 to 6 weeks
• at 4 to 6 weeks
• 10-fold fewer at 4 to 6 weeks

growth/size/body


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory