Phenotypes Associated with This Genotype

Genotype
MGI:4839213

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Gdf9-icre)5092Coo/0
• Genetic Background: B6.Cg-Pten^tm1Hwu Tg(Gdf9-icre)5092Coo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal oocyte morphology ( J:131827 )

♀ • accelerated oocyte growth

♀ • many transient follicles contain degraded oocytes

growth/size/body

enlarged ovary ( J:131827 )

♀ • at P8, ovaries appear larger with more activated follicles

♀ • by P23 and 35, ovaries remain larger and contain more activated follicles

endocrine/exocrine glands

abnormal corpus luteum morphology ( J:131827 )

♀ • luteolysis is observed (degeneration of corpora lutea) at 12 weeks of age

abnormal ovarian follicle morphology ( J:131827 )

♀ • at P8, ovaries appear larger with more activated follicles, including transient follicles containing enlarged oocytes surrounded by flattened pregranulosa cells, primary follicles with enlarged oocytes surrounded by one layer of cuboidal granulosa cells and some secondary follicles with two layers of granulosa cells

♀ • follicular structure at 12 weeks of age is deformed and luteolysis is observed

♀ • reduction in follicle death and clearance before and around the time of sexual maturity

♀ • at 7 weeks of age, ovaries show increased numbers of transient and preantral type 5 follicles

abnormal ovarian folliculogenesis ( J:131827 )

♀ • growth dynamics of activated transient follicles is different than in controls, with some follicles remaining at the transient stage whereas others develop further

abnormal primordial ovarian follicle morphology ( J:131827 )

♀ • premature activation of the primordial follicle pool resulting in depletion of primordial follicles in early adulthood

decreased primordial ovarian follicle number ( J:131827 )

♀ • percentage of primordial follicles in ovaries at P8 is lower (49.6%) than in controls (83.6%)

absent primordial ovarian follicles ( J:131827 )

♀ • by P23, no primordial follicles can be identified in mutants compared to 69.2% of follicles in controls areas are still at the primordial stage

enlarged ovary ( J:131827 )

♀ • at P8, ovaries appear larger with more activated follicles

♀ • by P23 and 35, ovaries remain larger and contain more activated follicles

premature ovarian failure ( J:131827 )

♀ • females exhibit activation of the pool of primordial follicles that leads to follicle depletion, causing premature ovarian failure

♀ • many transient follicles contain degraded oocytes suggesting that some prematurely activated follicles undergo atresia

homeostasis/metabolism

increased follicle stimulating hormone level ( J:131827 )

• increase in levels of follicle-stimulating hormone at 12-20-week old females

increased luteinizing hormone level ( J:131827 )

• increase in levels of luteinizing hormone at 12-20-week old females

mortality/aging

premature ovarian failure ( J:131827 )

♀ • females exhibit activation of the pool of primordial follicles that leads to follicle depletion, causing premature ovarian failure

♀ • many transient follicles contain degraded oocytes suggesting that some prematurely activated follicles undergo atresia

reproductive system

abnormal oocyte morphology ( J:131827 )

♀ • accelerated oocyte growth

♀ • many transient follicles contain degraded oocytes

abnormal corpus luteum morphology ( J:131827 )

♀ • luteolysis is observed (degeneration of corpora lutea) at 12 weeks of age

abnormal ovarian follicle morphology ( J:131827 )

♀ • at P8, ovaries appear larger with more activated follicles, including transient follicles containing enlarged oocytes surrounded by flattened pregranulosa cells, primary follicles with enlarged oocytes surrounded by one layer of cuboidal granulosa cells and some secondary follicles with two layers of granulosa cells

♀ • follicular structure at 12 weeks of age is deformed and luteolysis is observed

♀ • reduction in follicle death and clearance before and around the time of sexual maturity

♀ • at 7 weeks of age, ovaries show increased numbers of transient and preantral type 5 follicles

abnormal ovarian folliculogenesis ( J:131827 )

♀ • growth dynamics of activated transient follicles is different than in controls, with some follicles remaining at the transient stage whereas others develop further

abnormal primordial ovarian follicle morphology ( J:131827 )

♀ • premature activation of the primordial follicle pool resulting in depletion of primordial follicles in early adulthood

decreased primordial ovarian follicle number ( J:131827 )

♀ • percentage of primordial follicles in ovaries at P8 is lower (49.6%) than in controls (83.6%)

absent primordial ovarian follicles ( J:131827 )

♀ • by P23, no primordial follicles can be identified in mutants compared to 69.2% of follicles in controls areas are still at the primordial stage

enlarged ovary ( J:131827 )

♀ • at P8, ovaries appear larger with more activated follicles

♀ • by P23 and 35, ovaries remain larger and contain more activated follicles

premature ovarian failure ( J:131827 )

♀ • females exhibit activation of the pool of primordial follicles that leads to follicle depletion, causing premature ovarian failure

♀ • many transient follicles contain degraded oocytes suggesting that some prematurely activated follicles undergo atresia

abnormal estrous cycle ( J:131827 )

♀ • older females exhibit irregular estrous cycles

female infertility ( J:131827 )

♀ • females become infertile in early adulthood, after 12-13 weeks of age