Phenotypes Associated with This Genotype

Genotype
MGI:4839087

• Allelic Composition: Spp1^tm1Rit/Spp1^tm1Rit
• Genetic Background: B6.129S7-Spp1^tm1Rit

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal liver morphology ( J:93915 )

• considerably less liver damage induced by concanavalin A injection than in controls

• as measured by alanine transaminase levels

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:93915 )

• considerably less liver damage induced by concanavalin A injection than in controls

• as measured by alanine transaminase levels

immune system

decreased interferon-gamma secretion ( J:93915 )

• in the liver after concanavalin A injection relative to controls

decreased tumor necrosis factor secretion ( J:93915 )

• in the liver after concanavalin A injection relative to controls

decreased acute inflammation ( J:93915 )

• significantly reduced infiltration of neutrophiles into the liver after concanavalin A injection