Phenotypes Associated with This Genotype

Genotype
MGI:4838774

• Allelic Composition: Fas^lpr/Fas^lpr; Ifnar1^tm1Agt/Ifnar1^tm1Agt
• Genetic Background: MRL.Cg-Ifnar1^tm1Agt Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

salivary gland inflammation ( J:92084 )

• worse than in Fas^lpr homozygotes

increased IgA level ( J:92084 )

• compared with Fas^lpr homozygotes

increased IgG level ( J:92084 )

• mice exhibit IgG deposits in the kidney unlike wild-type mice

increased IgG2b level ( J:92084 )

• compared with Fas^lpr homozygotes

increased IgG3 level ( J:92084 )

• compared with Fas^lpr homozygotes

increased IgM level ( J:92084 )

• compared with Fas^lpr homozygotes

enlarged lymph nodes ( J:92084 )

increased susceptibility to systemic lupus erythematosus ( J:92084 )

• mice exhibit increased serum levels of kappa-chain rheumatoid factor and DNA auto-antibodies, lymphadenopathy, glomerulonephritis, renal immunoglobulin deposits, proteinuria, and end organ disease compared to in wild-type mice

• some systemic lupus erythematosus symptoms are more severe than Fas^lpr homozygotes

increased autoantibody level ( J:92084 )

• mice exhibit increased serum levels of kappa-chain rheumatoid factor compared to in wild-type mice and Fas^lpr homozygotes

increased anti-nuclear antigen antibody level ( J:92084 )

• DNA auto-antibodies are increased compared to in wild-type mice at 12 weeks

glomerulonephritis ( J:92084 )

renal/urinary system

increased urine protein level ( J:92084 )

glomerulonephritis ( J:92084 )

homeostasis/metabolism

increased urine protein level ( J:92084 )

endocrine/exocrine glands

salivary gland inflammation ( J:92084 )

• worse than in Fas^lpr homozygotes

digestive/alimentary system

salivary gland inflammation ( J:92084 )

• worse than in Fas^lpr homozygotes

hematopoietic system

increased IgA level ( J:92084 )

• compared with Fas^lpr homozygotes

increased IgG level ( J:92084 )

• mice exhibit IgG deposits in the kidney unlike wild-type mice

increased IgG2b level ( J:92084 )

• compared with Fas^lpr homozygotes

increased IgG3 level ( J:92084 )

• compared with Fas^lpr homozygotes

increased IgM level ( J:92084 )

• compared with Fas^lpr homozygotes