Phenotypes Associated with This Genotype

Genotype
MGI:4838405

• Allelic Composition: Wls^tm1.1Lan/Wls^tm1.1Lan; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:164701 )

embryo

short rostral-caudal axis ( J:164701 )

• mutant mice exhibit a shortened anteroposterior axis

abnormal neural tube morphology ( J:164701 )

• mutant phenotype is obvious as early as E9.5 due to the presence of a shortened neural tube

nervous system

abnormal neural tube morphology ( J:164701 )

• mutant phenotype is obvious as early as E9.5 due to the presence of a shortened neural tube

absent midbrain-hindbrain boundary ( J:164701 )

• mutant mice exhibit no apparent isthmus

decreased forebrain size ( J:164701 )

• at E12.5 a severely truncated forebrain

absent choroid plexus ( J:164701 )

• at E12.5

absent midbrain ( J:164701 )

• absent midbrain

abnormal metencephalon morphology ( J:164701 )

• at E10.5 verified deletion of regions of the metencephalon

absent cerebellum ( J:164701 )

• at E12.5