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Phenotypes Associated with This Genotype
Genotype
MGI:4838320
Allelic
Composition
Nf1tm1Par/Nf1tm1Fcr
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (24 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (24 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas (J:165209)
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas (J:165209)

immune system
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas (J:165209)
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas (J:165209)

nervous system
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas (J:165209)
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas (J:165209)
• irregularly shaped and thickened astrocytes are seen in the pre-chiasmatic optic nerves (J:165209)
• irregularly shaped and thickened astrocytes are seen in the pre-chiasmatic optic nerves (J:165209)
• retinal ganglion cell loss in the middle and peripheral region (J:165209)
• retinal ganglion cell loss in the middle and peripheral region (J:165209)
• optic gliomas form in the pre-chiasmatic optic nerve/optic chiasm, with increased vascularization to the area, abnormally shaped and thickened astrocytes, increase in microglia, and axonal and myelin degeneration (J:165209)
• mice exhibit abnormal optic nerve axon organization (J:165209)
• optic gliomas form in the pre-chiasmatic optic nerve/optic chiasm, with increased vascularization to the area, abnormally shaped and thickened astrocytes, increase in microglia, and axonal and myelin degeneration (J:165209)
• mice exhibit abnormal optic nerve axon organization (J:165209)
• the optic chiasm/nerves at 9 months of age appear as gross fusiform enlargements that result in optic gliomas (J:165209)
• increase in vascularization in the pre-chiasmatic optic nerve and optic chiasm (and in the optic glioma) (J:165209)
• the optic chiasm/nerves at 9 months of age appear as gross fusiform enlargements that result in optic gliomas (J:165209)
• increase in vascularization in the pre-chiasmatic optic nerve and optic chiasm (and in the optic glioma) (J:165209)
• axonal and myelin degeneration are seen in the optic nerve (J:165209)
• axonal and myelin degeneration are seen in the optic nerve (J:165209)
• increase in neoplastic astrocyte proliferation in the optic glioma (J:165209)
• increase in neoplastic astrocyte proliferation in the optic glioma (J:165209)
• disruption of the myelin is seen in the optic nerve, including degeneration and hypermyelination (J:165209)
• disruption of the myelin is seen in the optic nerve, including degeneration and hypermyelination (J:165209)
• hypermyelination is seen in the optic nerve (J:165209)
• hypermyelination is seen in the optic nerve (J:165209)

tumorigenesis
• mice develop optic gliomas in the optic chiasm/nerves (J:165209)
• optic gliomas appear as gross thickenings and enlargements of the pre-chiasmic nerve at 9 months of age (J:165209)
• mice develop optic gliomas in the optic chiasm/nerves (J:165209)
• optic gliomas appear as gross thickenings and enlargements of the pre-chiasmic nerve at 9 months of age (J:165209)

vision/eye
• retinal ganglion cell loss in the middle and peripheral region (J:165209)
• retinal ganglion cell loss in the middle and peripheral region (J:165209)
• optic gliomas form in the pre-chiasmatic optic nerve/optic chiasm, with increased vascularization to the area, abnormally shaped and thickened astrocytes, increase in microglia, and axonal and myelin degeneration (J:165209)
• mice exhibit abnormal optic nerve axon organization (J:165209)
• optic gliomas form in the pre-chiasmatic optic nerve/optic chiasm, with increased vascularization to the area, abnormally shaped and thickened astrocytes, increase in microglia, and axonal and myelin degeneration (J:165209)
• mice exhibit abnormal optic nerve axon organization (J:165209)
• the optic chiasm/nerves at 9 months of age appear as gross fusiform enlargements that result in optic gliomas (J:165209)
• increase in vascularization in the pre-chiasmatic optic nerve and optic chiasm (and in the optic glioma) (J:165209)
• the optic chiasm/nerves at 9 months of age appear as gross fusiform enlargements that result in optic gliomas (J:165209)
• increase in vascularization in the pre-chiasmatic optic nerve and optic chiasm (and in the optic glioma) (J:165209)

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:165209


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory