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Phenotypes Associated with This Genotype
Genotype
MGI:4838319
Allelic
Composition		 Cdkn1btm1Ako/Cdkn1b+
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0
Genetic
Background		 129S1.Cg-Cdkn1btm1Ako Tg(TPO-cre)1Shk Ptentm2.1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Ako mutation (0 available); any Cdkn1b mutation (26 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (86 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:165293 )
• mean survival is 58 weeks of age

neoplasm
increased thyroid adenoma incidence ( J:165293 )
• no sex differences in development of adenomas
increased thyroid carcinoma incidence ( J:165293 )
• no sex differences in development of carcinomas

endocrine/exocrine glands
increased thyroid adenoma incidence ( J:165293 )
• no sex differences in development of adenomas
increased thyroid carcinoma incidence ( J:165293 )
• no sex differences in development of carcinomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory