Mouse Genome Informatics
cn
    Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0

129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• females have a reduced lifespan compared to males, with a mean survival age of 73 weeks compared to 83 weeks in males
• mutants start to show signs of illness starting after 1 year of age

endocrine/exocrine glands
• enlarged thyroid
• ovariectomization of females results in reduced proliferative index of thyroids to a similar level seen in males

homeostasis/metabolism
• aging mice exhibit suppression of thyroid-stimulating hormone
• thyroxine levels are slightly, but significantly, increased in all mice with adenomas

tumorigenesis
• 52% of females develop thyroid follicular adenomas between 8-12 months of age compared to 12% of males
• 50% of the females and 35% of males over one year of age develop invasive and often metastatic thyroid follicular carcinomas

Mouse Models of Human Disease
OMIM IDRef(s)
Thyroid Carcinoma, Follicular; FTC 188470 J:165293