Phenotypes Associated with This Genotype

Genotype
MGI:4838029

• Allelic Composition: Pip5k1c^tm1.2Ref/Pip5k1c^tm1.2Ref; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased dendritic cell number ( J:164732 )

decreased B cell number ( J:164732 )

abnormal T cell physiology ( J:164732 )

• adhesion to ICAM-1 is increased compared to in wild-type cells

• T cell-APC conjugate formation is decreased compared to in wild-type cells

increased T cell proliferation ( J:164732 )

• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells

increased interferon-gamma secretion ( J:164732 )

• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies

increased interleukin-2 secretion ( J:164732 )

• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies

hematopoietic system

decreased dendritic cell number ( J:164732 )

decreased B cell number ( J:164732 )

abnormal T cell physiology ( J:164732 )

• adhesion to ICAM-1 is increased compared to in wild-type cells

• T cell-APC conjugate formation is decreased compared to in wild-type cells

increased T cell proliferation ( J:164732 )

• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells

cellular

increased T cell proliferation ( J:164732 )

• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells