Phenotypes Associated with This Genotype

Genotype
MGI:4837859

• Allelic Composition: Fas^lpr/Fas^lpr; Nos2^tm1Mrl/Nos2^tm1Mrl
• Genetic Background: involves: 129S7/SvEvBrd * MRL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urine homeostasis ( J:42666 )

• protein excretion less than controls at 20 weeks of age but not significantly

decreased urine nitrite level ( J:42666 )

• excrete very low levels of nitrite/nitrate relative to controls, heterozygotes are intermediate

• serum and urine levels of nitrite/nitrate are similar

homeostasis/metabolism

abnormal blood homeostasis ( J:42666 )

• serum and urine levels of nitrite/nitrate are similar

abnormal urine homeostasis ( J:42666 )

• protein excretion less than controls at 20 weeks of age but not significantly

decreased urine nitrite level ( J:42666 )

• excrete very low levels of nitrite/nitrate relative to controls, heterozygotes are intermediate

• serum and urine levels of nitrite/nitrate are similar

immune system

immune system phenotype ( J:42666 )

N • vasculitis absent in renal vessels, unlike controls

N • anti-DNA levels similar to controls

abnormal immunoglobulin level ( J:42666 )

• IgG1/IgG3 ratio is higher than controls

decreased IgG level ( J:42666 )

• significantly reduced rheumatoid factor specific IgG antibodies

decreased IgM level ( J:42666 )

• significantly reduced rheumatoid factor specific IgM antibodies

hematopoietic system

abnormal immunoglobulin level ( J:42666 )

• IgG1/IgG3 ratio is higher than controls

decreased IgG level ( J:42666 )

• significantly reduced rheumatoid factor specific IgG antibodies

decreased IgM level ( J:42666 )

• significantly reduced rheumatoid factor specific IgM antibodies