Phenotypes for Dbx1 Robo3 MGI:4837353 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dbx1^tm2(cre)Apie/Dbx1⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1^tm2(cre)Apie mutation (1 available); any Dbx1 mutation (25 available)
Robo3^tm1.1Ache mutation (0 available); any Robo3 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:165285 )

• mice do not survive after birth

nervous system

abnormal medulla oblongata morphology ( J:165285 )

• mice exhibit reduced biocytin stained commissural interneurons in the pre-Botzinger complex compared with wild-type mice

abnormal pre-Botzinger complex morphology ( J:165285 )

• mice exhibit reduced biocytin stained commissural interneurons in the pre-Botzinger complex compared with wild-type mice

abnormal pre-Botzinger complex physiology ( J:165285 )

• mice exhibit de-synchronization of rhythmic activity in the left and right pre-Botzinger complex compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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