Phenotypes Associated with This Genotype

Genotype
MGI:4837216

• Allelic Composition: \Fev^tm1Esd/\Fev^tm2Esd; \Tg(Fev-cre/ERT2)aEsd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:165266 )

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time and make fewer entrances into the open arms of an elevated plus maze

• however, the level of exploratory behavior in the elevated plus maze is normal

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend more time in the dark chamber in a light dark exploration assay

increased thigmotaxis ( J:165266 )

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time in the center of an open field

homeostasis/metabolism

decreased serotonin level ( J:165266 )

• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, brain levels of 5-HT and 5-HIAA are significantly decreased