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Phenotypes Associated with This Genotype
Genotype
MGI:4837213
Allelic
Composition		 Fevtm1Esd/Fevtm2Esd
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Fev-cre)1Esd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (14 available)
Fevtm2Esd mutation (0 available); any Fev mutation (14 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Fev-cre)1Esd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatosensory cortex morphology ( J:165266 )
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
abnormal innervation ( J:165266 )
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
abnormal serotonergic neuron morphology ( J:165266 )
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
abnormal nervous system electrophysiology ( J:165266 )
• neither high nor low concentrations of 8-Hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) elicit a change in baseline currents in labeled 5HT neurons
abnormal action potential ( J:165266 )
• YFP+ cells show increased spontaneous firing of action potentials

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory