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Phenotypes Associated with This Genotype
Genotype
MGI:4837213
Allelic
Composition
Fevtm1Esd/Fevtm2Esd
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Fev-cre)1Esd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (9 available)
Fevtm2Esd mutation (0 available); any Fev mutation (9 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (5 available); any Gt(ROSA)26Sor mutation (497 available)
Tg(Fev-cre)1Esd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
• neither high nor low concentrations of 8-Hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) elicit a change in baseline currents in labeled 5HT neurons
• YFP+ cells show increased spontaneous firing of action potentials


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory