Phenotypes Associated with This Genotype

Genotype
MGI:4837145

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)105Ayn/0
• Genetic Background: FVB.Cg-Trp53^tm1Brn Rb1^tm2Brn Tg(MMTV-cre)105Ayn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:165292 )

• 15 of 17 mice develop mammary neoplasms

• mammary tumor cells exhibit increased genomic instability compared to in Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)105Ayn mice

increased tumor growth/size ( J:165292 )

• cell proliferation in mammary carcinomas is increased compared to in Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)105Ayn mice

increased carcinoma incidence ( J:165292 )

• 10 of 43 neoplasms are well-differentiated carcinomas

• while one tumor is an adenosquamous carcinoma the remaining tumors are poorly differentiated carcinomas with spindle or polygonal, frequently pleomorphic cells

increased squamous cell carcinoma incidence ( J:165292 )

• 1 adenosquamous carcinoma

increased lung tumor incidence ( J:165292 )

• 4 of 40 mice develop lung metastasis

cellular

chromosomal instability ( J:165292 )

• mammary tumor cells exhibit increased genomic instability compared to in Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)105Ayn mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165292 )

• 15 of 17 mice develop mammary neoplasms

• mammary tumor cells exhibit increased genomic instability compared to in Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)105Ayn mice

integument

increased mammary gland tumor incidence ( J:165292 )

• 15 of 17 mice develop mammary neoplasms

• mammary tumor cells exhibit increased genomic instability compared to in Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)105Ayn mice

respiratory system

increased lung tumor incidence ( J:165292 )

• 4 of 40 mice develop lung metastasis