Phenotypes Associated with This Genotype

Genotype
MGI:4837112

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Plp1-cre/ERT2)1Ueli/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain white matter morphology ( J:161841 )

• mice treated with tamoxifen to induce cre-recombination exhibit an increase in white matter volume

abnormal corpus callosum morphology ( J:161841 )

• many axons in the corpus callosum are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination

abnormal myelin sheath morphology ( J:161841 )

• increase in myelin sheath thickness

• outfoldings of the myelin sheaths in CNS and PNS are observed

tomacula ( J:368191 )

• 2-month-old mice treated with tamoxifen for 10 consecutive days exhibit tomacula 3.5 months later

abnormal optic nerve morphology ( J:161841 )

• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination

hypermyelination ( J:161841 , J:368191 )

• many axons in the corpus callosum and optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination (J:161841)

• normally nonmyelinated C-fiber axons are spirally enwrapped by Remak Schwann cells are seen in mice treated with tamoxifen to induce cre-recombination (J:161841)

• 2-month-old mice treated with tamoxifen for 10 consecutive days exhibit myelin abnormalities 3.5 months later, including comma-shaped outfoldings, recurrent loops and tomacula (J:368191)

vision/eye

abnormal optic nerve morphology ( J:161841 )

• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination