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Phenotypes Associated with This Genotype
Genotype
MGI:4837112
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (36 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice treated with tamoxifen to induce cre-recombination exhibit an increase in white matter volume
• many axons in the corpus callosum are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination
• increase in myelin sheath thickness
• outfoldings of the myelin sheaths in CNS and PNS are observed
• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination
• many axons in the corpus callosum and optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination
• normally nonmyelinated C-fiber axons are spirally enwrapped by Remak Schwann cells are seen in mice treated with tamoxifen to induce cre-recombination

vision/eye
• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory