Phenotypes Associated with This Genotype

Genotype
MGI:4836993

• Allelic Composition: Mdm2^tm1.1Ypz/Mdm2^tm1.1Ypz; Tg(IghMyc)22Bri/0
• Genetic Background: B6.Cg-Mdm2^tm1.1Ypz Tg(IghMyc)22Bri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164200 )

• median survival is 9 weeks

immune system

enlarged thymus ( J:164200 )

spleen hyperplasia ( J:164200 )

enlarged Peyer's patches ( J:164200 )

enlarged lymph nodes ( J:164200 )

neoplasm

increased lymphoma incidence ( J:164200 )

• lymphomagenesis is accelerated compared to in Tg(IghMyc)22Bri mice

liver/biliary system

enlarged liver ( J:164200 )

hematopoietic system

enlarged thymus ( J:164200 )

spleen hyperplasia ( J:164200 )

endocrine/exocrine glands

enlarged thymus ( J:164200 )

growth/size/body

enlarged liver ( J:164200 )

spleen hyperplasia ( J:164200 )