Phenotypes Associated with This Genotype

Genotype
MGI:4836601

• Allelic Composition: Tgfbr1^tm1Karl/Tgfbr1^tm1.1Karl; Tg(GATA5-cre)1Krc/0
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157922 )

• die after birth

respiratory system

abnormal lung development ( J:157922 )

• late lung development is blocked such that lungs appear more cellular and contain immature alveoli and reduced airspace in distal lungs at E18.5 compared to wild-type

• marker analysis indicates that bronchiolar epithelial progenitor cell differentiation is impaired, however alveolar epithelial cell differentiation appears normal

abnormal bronchiole epithelium morphology ( J:157922 )

• bronchiolar epithelial progenitor cell differentiation is impaired

decreased club cell number ( J:157922 )

• Clara cell numbers are reduced in E18.5 lungs

small lung ( J:157922 )

• lungs are smaller at E15.5

abnormal pulmonary alveolus morphology ( J:157922 )

• distal airways are composed of highly disorganized cells

dilated respiratory conducting tube ( J:157922 )

• enlarged airways in the lungs at E15.5

integument

abnormal skin development ( J:157922 )

• fail to develop ventral skin