Phenotypes Associated with This Genotype

Genotype
MGI:4835054

• Allelic Composition: Apc^tm2Rak/Apc⁺; Tg(Car1-cre)5Flt/0
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:164247 )

N

increased intestinal adenoma incidence ( J:164247 )

• visible gross tumors are observed by 10 weeks of age with no increase in incidence up to 20 weeks in about 20% of animals; two types of lesions (microadenomas and adenomas) are identifiable microscopically

• both lesion types are overrepresented in the distal colon; microadenomas are present in proximal colon as well

increased incidence of tumors by chemical induction ( J:164247 )

• over 60% of mice receiving dextran sodium sulfate (DSS) for 7 days starting at 10 weeks of age have grossly visible adenomatous lesions in the colon with over 70% of the lesions found in the distal colon; mortality is observed in 55% of animals within 4 days of end of treatment, with remainder of treated mice surviving until end point of study at 15 weeks

• about 50% of mice receiving DSS for 5 days starting at 10 weeks of age develop visible tumors by 20 weeks of age with all lesions in the distal colon; mortality is observed in 20% of animals within 4 days of end of treatment, with remainder of treated mice surviving until end point of study at 15 weeks

• some microadenomas are observed in the cecum after DSS treatment

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:164247 )

N • no differences in body weight are observed relative to wild-type even when animals have tumors

increased incidence of tumors by chemical induction ( J:164247 )

• over 60% of mice receiving dextran sodium sulfate (DSS) for 7 days starting at 10 weeks of age have grossly visible adenomatous lesions in the colon with over 70% of the lesions found in the distal colon; mortality is observed in 55% of animals within 4 days of end of treatment, with remainder of treated mice surviving until end point of study at 15 weeks

• about 50% of mice receiving DSS for 5 days starting at 10 weeks of age develop visible tumors by 20 weeks of age with all lesions in the distal colon; mortality is observed in 20% of animals within 4 days of end of treatment, with remainder of treated mice surviving until end point of study at 15 weeks

• some microadenomas are observed in the cecum after DSS treatment

digestive/alimentary system

melena ( J:164247 )

• some mice with tumors produce bloody stool

colon polyps ( J:164247 )

• some adenomatous polyps are identifiable as sessile or pedunculated

increased intestinal adenoma incidence ( J:164247 )

• visible gross tumors are observed by 10 weeks of age with no increase in incidence up to 20 weeks in about 20% of animals; two types of lesions (microadenomas and adenomas) are identifiable microscopically

• both lesion types are overrepresented in the distal colon; microadenomas are present in proximal colon as well

hematopoietic system

anemia ( J:164247 )

• mice with tumors are mildly anemic

decreased hematocrit ( J:164247 )

• hematocrit of mice is 37% vs 48% in wild-type