Phenotypes Associated with This Genotype

Genotype
MGI:4835053

• Allelic Composition: Apc^tm2Rak/Apc^tm2Rak; Tg(Car1-cre)5Flt/0
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164247 )

• mice are able to survive up to 6 weeks of age

growth/size/body

decreased body weight ( J:164247 )

• body weights are reduced by 12.8% at 3 weeks and by 20% at 6 weeks

neoplasm

increased intestinal adenoma incidence ( J:164247 )

• raised lesions are observed in large intestine at 3 and 6 weeks

• affected areas display mucosal thickening, characterized by dysplastic epithelial cells with increased nuclear to cytoplasmic ratios and increased mitotic figures typical of microadenomas

• by 6 weeks, microadenomas and adenomas are multifocally distributed throughout distal and proximal colon

• lesions exhibit cytoplasmic and nuclear accumulation of beta-catenin in dysplastic epithelial cells; proliferation of these cells is increased, and extends beyond the crypt base

digestive/alimentary system

rectal prolapse ( J:164247 )

• all mice develop rectal prolapse by 3 weeks of age

increased intestinal adenoma incidence ( J:164247 )

• raised lesions are observed in large intestine at 3 and 6 weeks

• affected areas display mucosal thickening, characterized by dysplastic epithelial cells with increased nuclear to cytoplasmic ratios and increased mitotic figures typical of microadenomas

• by 6 weeks, microadenomas and adenomas are multifocally distributed throughout distal and proximal colon

• lesions exhibit cytoplasmic and nuclear accumulation of beta-catenin in dysplastic epithelial cells; proliferation of these cells is increased, and extends beyond the crypt base

hematopoietic system

decreased hematocrit ( J:164247 )

• hematocrit is decreased by >40% compared to Apc^tm2Rak/+ Tg(Car1-cre)5Flt mutants