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Phenotypes Associated with This Genotype
Genotype
MGI:4835047
Allelic
Composition		 Krastm4Tyj/Kras+
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129S4/SvJae * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased melanoma incidence ( J:164588 )
• 1 in 14 tamoxifen treated mice develops melanoma with a median tumor latency greater than 52 weeks

pigmentation
abnormal melanocyte morphology ( J:164588 )
• tamoxifen-treated mice exhibit melanocytic proliferation unlike wild-type mice
hyperpigmentation ( J:164588 )
• tamoxifen-treated mice develop pigmented macules in the paws and tail unlike wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory