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Phenotypes Associated with This Genotype
Genotype
MGI:4835045
Allelic
Composition		 Cdkn2atm2.1Nesh/Cdkn2a+
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53+
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm2.1Nesh mutation (4 available); any Cdkn2a mutation (67 available)
Krastm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased spindle cell carcinoma incidence ( J:164588 )
• tamoxifen-treated mice develop melanomas with spindle-like morphology
increased melanoma incidence ( J:164588 )
• 3 of 7 (43%) mice treated with tamoxifen neonatally develop melanomas with spindle-like morphology at a median latency greater than 52 weeks compared with Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh Krastm4Tyj/Kras+ Trp53tm1Brn/Trp53tm1Brn Tg(Tyr-cre/ERT2)13Bos mice whose median latency is 14 weeks

pigmentation
abnormal melanocyte morphology ( J:164588 )
• tamoxifen-treated mice exhibit melanocytic proliferation unlike wild-type mice
hyperpigmentation ( J:164588 )
• tamoxifen-treated mice develop pigmented macules in the paws and tail unlike wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory