Phenotypes for Hr Ptger2 MGI:4834868 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hr^hr/Hr^hr Ptger2^tm1Brey/Ptger2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (18 available); any Hr mutation (89 available)
Ptger2^tm1Brey mutation (6 available); any Ptger2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:117581 )

N	• unlike mice homozygous for both alleles, mice heterozygous for Ptger2^tm1Brey do not show any protection against tumor formation following a 15 week escalating light dose protocol

integument

abnormal skin physiology ( J:117581 )

• after a modest UVR exposure (180 mJ/cm²) keratinocyte proliferation is significantly lower compared to wild-type controls

• however, keratinocyte proliferation following higher levels of UVR exposure is similar to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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