Phenotypes Associated with This Genotype

Genotype
MGI:4834867

• Allelic Composition: Hr^hr/Hr^hr; Ptger2^tm1Brey/Ptger2^tm1Brey
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SKH1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by UV induction ( J:117581 )

• develop about half as many tumors as wild-type mice following a 15 week escalating light dose protocol

abnormal tumor morphology ( J:117581 )

• UVR induced tumors are more erythematous and have less keratinization

• UVR induced tumors are more likely to be poorly differentiated and deeply invasive compared to tumors in wild-type mice

increased tumor growth/size ( J:117581 )

• while the total number of tumors is reduced, the number of larger lesions (greater than 10 mm in diameter) is increased

integument

abnormal skin physiology ( J:117581 )

• after a modest UVR exposure (180 mJ/cm²) keratinocyte proliferation is significantly lower compared to wild-type controls

• however, keratinocyte proliferation following higher levels of UVR exposure is similar to wild-type controls

homeostasis/metabolism

decreased incidence of tumors by UV induction ( J:117581 )

• develop about half as many tumors as wild-type mice following a 15 week escalating light dose protocol