Phenotypes Associated with This Genotype

Genotype
MGI:4834818

• Allelic Composition: Tg(Msx2-En1)86Alj/Tg(Msx2-En1)86Alj
• Genetic Background: involves: Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:62572 )

abnormal digit morphology ( J:62572 )

• in some animals (20%), only digits 4-5 are malformed

adactyly ( J:62572 )

• in many animals (70%), forelimbs have only 1-2 digits

abnormal forelimb morphology ( J:62572 )

• forelimbs are less severely affected than hindlimbs

• forelimbs often lack some digits (70%) except 1-2; 10% of animals show a truncation below the humerus

abnormal hindlimb morphology ( J:62572 )

• all mice display limb deformities, with hemizygotes displaying less severe defects

abnormal femur morphology ( J:62572 )

• only small fragments of femur are present in severe cases

absent fibula ( J:62572 )

• some animals (20%) have tibia and distal cartilaginous fragments

absent hindlimb ( J:62572 )

• most animals lack hindlimbs, only small fragments of femur are present (80%)

skeleton

abnormal femur morphology ( J:62572 )

• only small fragments of femur are present in severe cases

absent fibula ( J:62572 )

• some animals (20%) have tibia and distal cartilaginous fragments