Phenotypes Associated with This Genotype

Genotype
MGI:4834753

• Allelic Composition: Lif^tm1Stw/Lif^tm1Stw
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:115507 )

N • brain histology appears normal

abnormal brain vasculature morphology ( J:137720 )

• capillary networks in the hindbrain plexus and fore limb are densely condensed compared to in wild-type mice

abnormal glial cell morphology ( J:89814 )

• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice

abnormal CNS glial cell morphology ( J:115507 )

• mice exhibit fewer GFAP+ glial cells are detected, especially in the stratum pyramidal, compared with wild-type mice

• however, the number of S100+ glial cells is normal

abnormal astrocyte morphology ( J:137720 )

• mice exhibit fewer GFAP+ astrocytes compared with wild-type mice

• astrocyte proliferation in the retina is increased compared to in wild-type mice until P6 to P8

integument

abnormal skin vasculature morphology ( J:137720 )

• at E11, microvessels in the trunk skin exhibit increased density compared to in wild-type mice

cellular

increased vascular endothelial cell proliferation ( J:137720 )

• endothelial proliferation in the retina is increased compared to in wild-type mice

cardiovascular system

abnormal blood vessel morphology ( J:137720 )

• microvessels in P4 trachea exhibit increased filopodia and branching compared to in wild-type mice

abnormal capillary morphology ( J:137720 )

• capillary networks in the hindbrain plexus and fore limb are densely condensed compared to in wild-type mice

abnormal brain vasculature morphology ( J:137720 )

• capillary networks in the hindbrain plexus and fore limb are densely condensed compared to in wild-type mice

abnormal retina vasculature morphology ( J:137720 )

• retinal vasculature exhibit increased endothelial filopodia and branching points and increased capillary density compared to in wild-type mice

abnormal induced retina neovascularization ( J:137720 )

• in a model of oxygen-induced retinopathy, mice exhibit increased extraretinal neovascularization compared with similarly treated wild-type mice

abnormal skin vasculature morphology ( J:137720 )

• at E11, microvessels in the trunk skin exhibit increased density compared to in wild-type mice

increased vascular endothelial cell proliferation ( J:137720 )

• endothelial proliferation in the retina is increased compared to in wild-type mice

growth/size/body

decreased body size ( J:119777 )

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:119777 )

• following exposure to complete Freund's adjuvant (CFA), mice exhibit a 9-fold increased in IL1beta compared with a 2-fold increase in similarly treated wild-type mice

decreased susceptibility to injury ( J:89814 , J:137720 )

• 24 hours after nerve crush injury, mice exhibit 3-fold less neutrophils, 1.7-fold less macrophages, and 1.8-fold less mast cells at the site of injury compared with similarly treated wild-type mice (J:89814)

• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice (J:89814)

• however, mice exhibit normal cell infiltration 7 days after nerve crush injury (J:89814)

• mice are resistant to hyperoxic insult on the retina compared with similarly treated wild-type mice (J:137720)

immune system

increased circulating interleukin-1 beta level ( J:119777 )

• following exposure to complete Freund's adjuvant (CFA), mice exhibit a 9-fold increased in IL1beta compared with a 2-fold increase in similarly treated wild-type mice

increased acute inflammation ( J:119777 )

• following exposure to complete Freund's adjuvant (CFA), mice exhibit increased swelling, IL1beta levels, and neutrophil infiltration (4.8-fold) compared with similarly treated wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:137720 )

• retinal vasculature exhibit increased endothelial filopodia and branching points and increased capillary density compared to in wild-type mice

abnormal induced retina neovascularization ( J:137720 )

• in a model of oxygen-induced retinopathy, mice exhibit increased extraretinal neovascularization compared with similarly treated wild-type mice