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Phenotypes Associated with This Genotype
Genotype
MGI:4834658
Allelic
Composition
Cyr61tm1Lfl/Cyr61+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyr61tm1Lfl mutation (0 available); any Cyr61 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E14.5, some mutant mice show dysplastic mitral valves (3/27) (J:126490)
• at E14.5, some mutant mice show dysplastic mitral valves (3/27) (J:126490)
• 20% of adult mutant mice (5/25) show persistent ASD, where the septum primum failed to fuse completely with the cushion tissue and the ostium primum remained (J:126490)
• septum secundum formation was normal, but the postnatal fusion of the two septa was precluded by the defective septum primum; consequently, blood cells were trapped between the atria and the hemodynamic flow was in disarray (J:126490)
• 20% of adult mutant mice (5/25) show persistent ASD, where the septum primum failed to fuse completely with the cushion tissue and the ostium primum remained (J:126490)
• septum secundum formation was normal, but the postnatal fusion of the two septa was precluded by the defective septum primum; consequently, blood cells were trapped between the atria and the hemodynamic flow was in disarray (J:126490)
• the foramen ovale remained patent in affected adult mice (J:126490)
• the foramen ovale remained patent in affected adult mice (J:126490)
• at E14.5, some mutant mice show complete AVSD (4/27) (J:126490)
• at E14.5, some mutant mice show complete AVSD (4/27) (J:126490)
• while a VSD in mutant hearts was apparent at E13.5 and E14.5, it is not seen after E15.5, indicating that interventricular septum formation is delayed in mutant embryos but not persistently impaired (J:126490)
• while a VSD in mutant hearts was apparent at E13.5 and E14.5, it is not seen after E15.5, indicating that interventricular septum formation is delayed in mutant embryos but not persistently impaired (J:126490)
• at E14.5, some mutant mice show VSD (11/27), but this is no longer apparent at E15.5 (J:126490)
• at E14.5, some mutant mice show VSD (11/27), but this is no longer apparent at E15.5 (J:126490)

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrial Septal Defect 1; ASD1 108800 J:126490


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory