Phenotypes Associated with This Genotype

Genotype
MGI:4834587

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺; Tardbp^tm1.1Pcw/Tardbp^tm1.1Pcw
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:164406 )

• when cre expression is induced with a tamoxifen-containing diet (400 mg/kg of chow), mice die by day 9 post-introduction of tamoxifen

growth/size/body

decreased body weight ( J:164406 )

• during the initial 3 days after cre induction by tamoxifen, all mice show decrease in body weight due to decreased food intake, but whereas controls regain recover some weight, experimental mice do not

weight loss ( J:164406 )

• mice show a cumulative loss of body weight compared to controls following cre induction, but energy intake (cumulative food intake) is similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:164406 )

N • without induction of cre by tamoxifen treatment, animals are indistinguishable from controls

abnormal lipid oxidation ( J:164406 )

• increased fat oxidation after induction is basis for increased weight loss

abnormal respiratory quotient ( J:164406 )

• following cre induction, animals exhibit a decreased respiratory exchange ratio (RER) indicative of pure fat oxidation compared to controls by day 6

adipose tissue

decreased total body fat amount ( J:164406 )

• inspection of animals dying after cre induction by tamoxifen shows loss of body fat in these mice

• analyses of carcasses show significant decreases in whole body fat mass, but not lean mass

cellular

abnormal lipid oxidation ( J:164406 )

• increased fat oxidation after induction is basis for increased weight loss

behavior/neurological

abnormal food intake ( J:164406 )

• energy intake on day 7 is significantly higher than on day 1 after cre induction