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Phenotypes Associated with This Genotype
Genotype
MGI:4834525
Allelic
Composition
AspmGt(AJ0069)Wtsi/AspmGt(AJ0069)Wtsi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AspmGt(AJ0069)Wtsi mutation (0 available); any Aspm mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• significant reduction in head area
• reduced track speed of motile sperm

nervous system
• brains of newborn and adult mice are significantly reduced in weight
• adult brains have a reduced neocortex area

reproductive system
• significant reduction in head area
• reduced track speed of motile sperm
• ovary weight is significantly reduced
• Testis weight in adult (10 wk) is drastically reduced
• when females mated with wild-type males they have significantly fewer embryos
• when males are mated with wild-type females they exhibit a much lower pregnancy rate

endocrine/exocrine glands
• ovary weight is significantly reduced
• Testis weight in adult (10 wk) is drastically reduced

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microcephaly DOID:10907 OMIM:251200
OMIM:604321
OMIM:604804
OMIM:608393
OMIM:608716
OMIM:612703
J:164424


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory