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Phenotypes Associated with This Genotype
Genotype
MGI:4834197
Allelic
Composition		 \Cx3cr1tm1Litt/\Cx3cr1+
\Psen1tm1Mpm/\Psen1tm1Mpm
\Tg(APPSwe,tauP301L)1Lfa/0
\Tg(Thy1-YFP)HJrs/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (47 available)
Psen1tm1Mpm mutation (4 available); any Psen1 mutation (57 available)
Tg(APPSwe,tauP301L)1Lfa mutation (3 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal microglial cell morphology ( J:159680 )
• microglial density increases over time around lost neurons unlike in Cx3cr1tm1Litt/Cx3cr1tm1Litt Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice
abnormal microglial cell physiology ( J:159680 )
• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1tm1Litt heterozygotes and homozygotes
neuron degeneration ( J:159680 )
• of YFP+ layer III neurons at 4 to 6 months

immune system
abnormal microglial cell morphology ( J:159680 )
• microglial density increases over time around lost neurons unlike in Cx3cr1tm1Litt/Cx3cr1tm1Litt Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice
abnormal microglial cell physiology ( J:159680 )
• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1tm1Litt heterozygotes and homozygotes

hematopoietic system
abnormal microglial cell morphology ( J:159680 )
• microglial density increases over time around lost neurons unlike in Cx3cr1tm1Litt/Cx3cr1tm1Litt Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice
abnormal microglial cell physiology ( J:159680 )
• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1tm1Litt heterozygotes and homozygotes

cellular
abnormal microglial cell morphology ( J:159680 )
• microglial density increases over time around lost neurons unlike in Cx3cr1tm1Litt/Cx3cr1tm1Litt Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice
abnormal microglial cell physiology ( J:159680 )
• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1tm1Litt heterozygotes and homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory