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Phenotypes Associated with This Genotype
Genotype
MGI:4834138
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic
Background		 B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (36 available)
Cx3cr1tm1Litt mutation (6 available); any Cx3cr1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:129712 )
• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice
increased susceptibility to experimental autoimmune encephalomyelitis ( J:129712 )
• mice exhibit the same severity of experimental autoimmune encephalomyelitis as Cx3cr1tm1Litt homozygotes

behavior/neurological
paralysis ( J:129712 )
• following induction of experimental autoimmune encephalomyelitis, mice exhibit nonremitting spastic paralysis

hematopoietic system
decreased NK cell number ( J:129712 )
• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory