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Phenotypes Associated with This Genotype
Genotype
MGI:4831134
Allelic
Composition		 Faimtm1Kplm/Faimtm1Kplm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faimtm1Kplm mutation (0 available); any Faim mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:164184 )
• mice die significantly earlier than wildtype in response to anti-FAS antibodies

immune system
increased B cell apoptosis ( J:164184 )
• more susceptible to activation induced cell death
increased thymocyte apoptosis ( J:164184 )
• enhanced susceptibility to FAS-induced apoptosis
liver inflammation ( J:164184 )
• more rapid progression of acute fulminant hepatitis in response to anti-FAS antibodies

hematopoietic system
increased B cell apoptosis ( J:164184 )
• more susceptible to activation induced cell death
increased thymocyte apoptosis ( J:164184 )
• enhanced susceptibility to FAS-induced apoptosis

liver/biliary system
liver hemorrhage ( J:164184 )
• within 2.5 hours after treatment with anti-FAS antibodies
increased hepatocyte apoptosis ( J:164184 )
• in response to anti-FAS antibodies
liver inflammation ( J:164184 )
• more rapid progression of acute fulminant hepatitis in response to anti-FAS antibodies
liver failure ( J:164184 )
• more rapid liver failure in response to anti-FAS antibodies

homeostasis/metabolism
increased circulating alanine transaminase level ( J:164184 )
• significant increase in the level of alanine aminotransferase in response to anti-FAS antibodies
increased susceptibility to xenobiotic induced morbidity/mortality ( J:164184 )
• mice die significantly earlier than wildtype in response to anti-FAS antibodies

cardiovascular system
liver hemorrhage ( J:164184 )
• within 2.5 hours after treatment with anti-FAS antibodies

cellular
increased B cell apoptosis ( J:164184 )
• more susceptible to activation induced cell death
increased thymocyte apoptosis ( J:164184 )
• enhanced susceptibility to FAS-induced apoptosis
increased hepatocyte apoptosis ( J:164184 )
• in response to anti-FAS antibodies

endocrine/exocrine glands
increased thymocyte apoptosis ( J:164184 )
• enhanced susceptibility to FAS-induced apoptosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory