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Phenotypes Associated with This Genotype
Genotype
MGI:4831003
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Tnfaip3tm2Ama/Tnfaip3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Tnfaip3tm2Ama mutation (0 available); any Tnfaip3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls
increased plasma cell number ( J:163917 )
• increase in percentage of splenic plasma cells
increased immunoglobulin level ( J:163917 )
• IgM and IgG deposits are seen in the kidneys
increased susceptibility to autoimmune disorder ( J:163917 )
• CpG treatment enhances production of IgG dsDNA antibodies in serum as well as deposition of IgG in renal glomeruli, indicating development of autoimmune disease

hematopoietic system
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls
increased plasma cell number ( J:163917 )
• increase in percentage of splenic plasma cells
increased immunoglobulin level ( J:163917 )
• IgM and IgG deposits are seen in the kidneys

cellular
decreased B cell apoptosis ( J:163917 )
• B cells are resistant to Fas-mediated programmed cell death compared to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory