Phenotypes Associated with This Genotype

Genotype
MGI:4830883

• Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:163663 )

• typically die 8-20 d after birth

growth/size/body

decreased body size ( J:163663 )

• dramatically runted animals by P8-P10

postnatal growth retardation ( J:163663 )

• mice exhibit progressive growth retardation, beginning at postnatal day P4-P5

immune system

increased neutrophil cell number ( J:163663 )

• immature and mature neutrophils on peripheral blood smear

abnormal spleen morphology ( J:163663 )

• authors state spleen exhibits features similar to the liver

increased inflammatory response ( J:163663 )

• systemic inflammation

liver inflammation ( J:163663 )

• histiocytic inflammatory infiltrates

myositis ( J:163663 )

lung inflammation ( J:163663 )

interstitial pneumonia ( J:163663 )

• multifocal suppurative and histiocytic interstitial and perivascular pneumonia

muscle

myositis ( J:163663 )

respiratory system

lung inflammation ( J:163663 )

interstitial pneumonia ( J:163663 )

• multifocal suppurative and histiocytic interstitial and perivascular pneumonia

hematopoietic system

extramedullary hematopoiesis ( J:163663 )

• extramedullary hematopoeisis with a predominance of myeloid and megakaryocytic cells

increased neutrophil cell number ( J:163663 )

• immature and mature neutrophils on peripheral blood smear

abnormal spleen morphology ( J:163663 )

• authors state spleen exhibits features similar to the liver

liver/biliary system

hepatic necrosis ( J:163663 )

• accompanied by dying hepatocytes

liver inflammation ( J:163663 )

• histiocytic inflammatory infiltrates

liver hypoplasia ( J:163663 )

• in rare aged mouse (3.5 months) liver is shrunken and distorted

liver fibrosis ( J:163663 )

• in rare aged mouse (3.5 months) liver is distorted by bridging fibrosis extending from the capsule through the parenchyma, multifocal capsular fibrosis and lymphocytic inflammation that extended into underlying parenchyma are also seen

nervous system

abnormal brain morphology ( J:163663 )

• authors state brain exhibits features similar to the liver

cardiovascular system

abnormal heart morphology ( J:163663 )

• authors state heart exhibits features similar to the liver

digestive/alimentary system

abnormal colon morphology ( J:163663 )

• authors state colon exhibits features similar to the liver

skeleton

abnormal bone structure ( J:163663 )

• authors state bone exhibits features similar to the liver

integument

epidermal necrosis ( J:163663 )

distorted hair follicle pattern ( J:163663 )

• shortened distorted hair follicles

small hair follicles ( J:163663 )

• shortend

epidermal hyperplasia ( J:163663 )

skin fibrosis ( J:163663 )

• suppurative dermatitis with dermal fibrosis and multifocal epidermal necrosis

cellular

epidermal necrosis ( J:163663 )

hepatic necrosis ( J:163663 )

• accompanied by dying hepatocytes